The impact of DNA tumor viruses in low-to-middle income countries (LMICS): A literature review
DNA viruses are common in the human population and act as aetiological agents of cancer on a large scale globally. They include the human papillomaviruses (HPV), Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV), hepatitis viruses, and human polyomaviruses. Oncogenic viruses emp...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Tumour Virus Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666679024000132 |
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| author | Bothwell Takaingofa Guzha Allen Matubu George Nyandoro Hamish O. Mubata Enos Moyo Grant Murewanhema Zvavahera M. Chirenje |
| author_facet | Bothwell Takaingofa Guzha Allen Matubu George Nyandoro Hamish O. Mubata Enos Moyo Grant Murewanhema Zvavahera M. Chirenje |
| author_sort | Bothwell Takaingofa Guzha |
| collection | DOAJ |
| description | DNA viruses are common in the human population and act as aetiological agents of cancer on a large scale globally. They include the human papillomaviruses (HPV), Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV), hepatitis viruses, and human polyomaviruses. Oncogenic viruses employ different mechanisms to induce cancer. Notably, cancer only develops in a minority of individuals who are infected, usually following protracted years of chronic infection. The human papillomaviruses (HPVs) are associated with the highest number of cancer cases, including cervical cancer and other epithelial malignancies. Hepatitis B virus (HBV) and the RNA virus hepatitis C (HCV) are significant contributors to hepatocellular cancer (HCC). Other oncoviruses include Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpes virus (KSHV), human T-cell leukemia virus (HTLV-I), and Merkel cell polyomavirus (MCPyV). The identification of these infectious agents as aetiological agents for cancer has led to reductions in cancer incidence through preventive interventions such as HBV and HPV vaccination, HPV-DNA based cervical cancer screening, antiviral treatments for chronic HBV and HCV infections, and screening of blood for transfusion for HBV and HCV. Successful efforts to identify additional oncogenic viruses in human cancer may provide further understanding of the aetiology and development of cancer, and novel approaches for prevention and treatment. Cervical cancer, caused by HPV, is the leading gynaecological malignancy in LMICs, with high age-standardised incidence and mortality rates, HCC due to HBV is an important cause of cancer deaths, and the burden of other cancer attributable to infections continues to rise globally. Hence, cancers attributable to DNA viruses have become a significant global health challenge. These viruses hence warrant continued attention and interrogation as efforts to understand them further and device further preventive interventions are critical. |
| format | Article |
| id | doaj-art-f340da6a0aaa4f1cb9d5589809cdddd3 |
| institution | Kabale University |
| issn | 2666-6790 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Tumour Virus Research |
| spelling | doaj-art-f340da6a0aaa4f1cb9d5589809cdddd32024-12-15T06:17:20ZengElsevierTumour Virus Research2666-67902024-12-0118200289The impact of DNA tumor viruses in low-to-middle income countries (LMICS): A literature reviewBothwell Takaingofa Guzha0Allen Matubu1George Nyandoro2Hamish O. Mubata3Enos Moyo4Grant Murewanhema5Zvavahera M. Chirenje6Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe; University of Zimbabwe Clinical Trials Research Centre, Harare, ZimbabweUniversity of Zimbabwe Clinical Trials Research Centre, Harare, ZimbabweHepatitis Alliance, 2172, Arlington, Hatfield, Harare, ZimbabweDepartment of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, ZimbabweSchool of Public Health Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South AfricaDepartment of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe; University of Zimbabwe Clinical Trials Research Centre, Harare, Zimbabwe; Corresponding author. Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences University of Zimbabwe, P.O Box A178, Avondale, Harare, Zimbabwe.University of Zimbabwe Clinical Trials Research Centre, Harare, Zimbabwe; Department of Obstetrics, Gynecology and Reproductive Science, University of California San Francisco, San Francisco, USADNA viruses are common in the human population and act as aetiological agents of cancer on a large scale globally. They include the human papillomaviruses (HPV), Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV), hepatitis viruses, and human polyomaviruses. Oncogenic viruses employ different mechanisms to induce cancer. Notably, cancer only develops in a minority of individuals who are infected, usually following protracted years of chronic infection. The human papillomaviruses (HPVs) are associated with the highest number of cancer cases, including cervical cancer and other epithelial malignancies. Hepatitis B virus (HBV) and the RNA virus hepatitis C (HCV) are significant contributors to hepatocellular cancer (HCC). Other oncoviruses include Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpes virus (KSHV), human T-cell leukemia virus (HTLV-I), and Merkel cell polyomavirus (MCPyV). The identification of these infectious agents as aetiological agents for cancer has led to reductions in cancer incidence through preventive interventions such as HBV and HPV vaccination, HPV-DNA based cervical cancer screening, antiviral treatments for chronic HBV and HCV infections, and screening of blood for transfusion for HBV and HCV. Successful efforts to identify additional oncogenic viruses in human cancer may provide further understanding of the aetiology and development of cancer, and novel approaches for prevention and treatment. Cervical cancer, caused by HPV, is the leading gynaecological malignancy in LMICs, with high age-standardised incidence and mortality rates, HCC due to HBV is an important cause of cancer deaths, and the burden of other cancer attributable to infections continues to rise globally. Hence, cancers attributable to DNA viruses have become a significant global health challenge. These viruses hence warrant continued attention and interrogation as efforts to understand them further and device further preventive interventions are critical.http://www.sciencedirect.com/science/article/pii/S2666679024000132DNA tumor virusesHPVHBVEBVKaposi sarcomaPolyoma |
| spellingShingle | Bothwell Takaingofa Guzha Allen Matubu George Nyandoro Hamish O. Mubata Enos Moyo Grant Murewanhema Zvavahera M. Chirenje The impact of DNA tumor viruses in low-to-middle income countries (LMICS): A literature review Tumour Virus Research DNA tumor viruses HPV HBV EBV Kaposi sarcoma Polyoma |
| title | The impact of DNA tumor viruses in low-to-middle income countries (LMICS): A literature review |
| title_full | The impact of DNA tumor viruses in low-to-middle income countries (LMICS): A literature review |
| title_fullStr | The impact of DNA tumor viruses in low-to-middle income countries (LMICS): A literature review |
| title_full_unstemmed | The impact of DNA tumor viruses in low-to-middle income countries (LMICS): A literature review |
| title_short | The impact of DNA tumor viruses in low-to-middle income countries (LMICS): A literature review |
| title_sort | impact of dna tumor viruses in low to middle income countries lmics a literature review |
| topic | DNA tumor viruses HPV HBV EBV Kaposi sarcoma Polyoma |
| url | http://www.sciencedirect.com/science/article/pii/S2666679024000132 |
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