Sessile Serrated Lesions: Searching for the True Prevalence and Risk Factors in China
Background/Aims: Growing recognition identifies sessile serrated lesions (SSL) as colorectal cancer (CRC) precursors. However, the SSL detection rate remains debatable and lacks a definitive consensus. Additionally, understanding the influencing factors in SSL development is limited. We aim to retro...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AVES
2025-01-01
|
| Series: | The Turkish Journal of Gastroenterology |
| Online Access: | https://www.turkjgastroenterol.org/en/sessile-serrated-lesions-searching-for-the-true-prevalence-and-risk-factors-in-china-137294 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841550151405010944 |
|---|---|
| author | Bing-Yue Yao Li Zhang Chuan-Xia Wu Liang Zheng Ben-Song Duan Qin-Wei Xu Jing-Jing Lian Hai-Bin Zhang Yu Wang Jia Cao |
| author_facet | Bing-Yue Yao Li Zhang Chuan-Xia Wu Liang Zheng Ben-Song Duan Qin-Wei Xu Jing-Jing Lian Hai-Bin Zhang Yu Wang Jia Cao |
| author_sort | Bing-Yue Yao |
| collection | DOAJ |
| description | Background/Aims: Growing recognition identifies sessile serrated lesions (SSL) as colorectal cancer (CRC) precursors. However, the SSL detection rate remains debatable and lacks a definitive consensus. Additionally, understanding the influencing factors in SSL development is limited. We aim to retrospectively analyze the true prevalence and risk factors of SSL in China.
Materials and Methods: This retrospective study collected medical data from patients who underwent colonoscopy at the Endoscopy Center of Shanghai East Hospital affiliated with Tongji University between March 1, 2019 and February 28, 2022. Data were sourced through the electronic medical record system and included information such as age, sex, lesion location, number, and pathology. This study predominantly focused on the detection rate and the clinical and endoscopic features of SSL.
Results: Of 72 287 colonoscopies in 3 years, 3905 cases were histologically confirmed as SSL. Among them, 2290 (58.6%) were male, and 1615 (41.4%) were female. The overall SSL detection rate was 5.40%, slightly surpassing Asian/Chinese averages but lower than Western rates. Males had a higher SSL detection rate (6.1%) than females (4.6%). Univariate analysis revealed a significant association between SSL with dysplasia/adenocarcinoma (SSL-D/AD) and obesity (Body Mass Index, BMI ≥ 24), CRC family history, and hypertension. After multivariable logistic regression, only obesity (BMI ≥ 24) remained a statistically significant independent risk factor for SSL-D/AD.
Conclusions: The SSL detection rate at our center is 5.4% and increases with age. Males have a significantly higher detection rate than females. Our findings suggest that endoscopists should consider risk factors for SSL-D/AD, such as obesity, CRC family history, and hypertension. |
| format | Article |
| id | doaj-art-f2fe2ede087f470e88d5f2d11edb764c |
| institution | Kabale University |
| issn | 2148-5607 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | AVES |
| record_format | Article |
| series | The Turkish Journal of Gastroenterology |
| spelling | doaj-art-f2fe2ede087f470e88d5f2d11edb764c2025-01-10T06:59:36ZengAVESThe Turkish Journal of Gastroenterology2148-56072025-01-01361152310.5152/tjg.2024.24188Sessile Serrated Lesions: Searching for the True Prevalence and Risk Factors in ChinaBing-Yue Yao0Li Zhang1Chuan-Xia Wu2 Liang Zheng3Ben-Song Duan4Qin-Wei Xu5Jing-Jing Lian6Hai-Bin Zhang7Yu Wang8Jia Cao9Department of Gastroenterology, Endoscopy Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Pathology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Gastroenterology, Linyi Central Hospital, Linyi, Shandong, ChinaHeart Failure Research Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaBackground/Aims: Growing recognition identifies sessile serrated lesions (SSL) as colorectal cancer (CRC) precursors. However, the SSL detection rate remains debatable and lacks a definitive consensus. Additionally, understanding the influencing factors in SSL development is limited. We aim to retrospectively analyze the true prevalence and risk factors of SSL in China. Materials and Methods: This retrospective study collected medical data from patients who underwent colonoscopy at the Endoscopy Center of Shanghai East Hospital affiliated with Tongji University between March 1, 2019 and February 28, 2022. Data were sourced through the electronic medical record system and included information such as age, sex, lesion location, number, and pathology. This study predominantly focused on the detection rate and the clinical and endoscopic features of SSL. Results: Of 72 287 colonoscopies in 3 years, 3905 cases were histologically confirmed as SSL. Among them, 2290 (58.6%) were male, and 1615 (41.4%) were female. The overall SSL detection rate was 5.40%, slightly surpassing Asian/Chinese averages but lower than Western rates. Males had a higher SSL detection rate (6.1%) than females (4.6%). Univariate analysis revealed a significant association between SSL with dysplasia/adenocarcinoma (SSL-D/AD) and obesity (Body Mass Index, BMI ≥ 24), CRC family history, and hypertension. After multivariable logistic regression, only obesity (BMI ≥ 24) remained a statistically significant independent risk factor for SSL-D/AD. Conclusions: The SSL detection rate at our center is 5.4% and increases with age. Males have a significantly higher detection rate than females. Our findings suggest that endoscopists should consider risk factors for SSL-D/AD, such as obesity, CRC family history, and hypertension.https://www.turkjgastroenterol.org/en/sessile-serrated-lesions-searching-for-the-true-prevalence-and-risk-factors-in-china-137294 |
| spellingShingle | Bing-Yue Yao Li Zhang Chuan-Xia Wu Liang Zheng Ben-Song Duan Qin-Wei Xu Jing-Jing Lian Hai-Bin Zhang Yu Wang Jia Cao Sessile Serrated Lesions: Searching for the True Prevalence and Risk Factors in China The Turkish Journal of Gastroenterology |
| title | Sessile Serrated Lesions: Searching for the True Prevalence and Risk Factors in China |
| title_full | Sessile Serrated Lesions: Searching for the True Prevalence and Risk Factors in China |
| title_fullStr | Sessile Serrated Lesions: Searching for the True Prevalence and Risk Factors in China |
| title_full_unstemmed | Sessile Serrated Lesions: Searching for the True Prevalence and Risk Factors in China |
| title_short | Sessile Serrated Lesions: Searching for the True Prevalence and Risk Factors in China |
| title_sort | sessile serrated lesions searching for the true prevalence and risk factors in china |
| url | https://www.turkjgastroenterol.org/en/sessile-serrated-lesions-searching-for-the-true-prevalence-and-risk-factors-in-china-137294 |
| work_keys_str_mv | AT bingyueyao sessileserratedlesionssearchingforthetrueprevalenceandriskfactorsinchina AT lizhang sessileserratedlesionssearchingforthetrueprevalenceandriskfactorsinchina AT chuanxiawu sessileserratedlesionssearchingforthetrueprevalenceandriskfactorsinchina AT liangzheng sessileserratedlesionssearchingforthetrueprevalenceandriskfactorsinchina AT bensongduan sessileserratedlesionssearchingforthetrueprevalenceandriskfactorsinchina AT qinweixu sessileserratedlesionssearchingforthetrueprevalenceandriskfactorsinchina AT jingjinglian sessileserratedlesionssearchingforthetrueprevalenceandriskfactorsinchina AT haibinzhang sessileserratedlesionssearchingforthetrueprevalenceandriskfactorsinchina AT yuwang sessileserratedlesionssearchingforthetrueprevalenceandriskfactorsinchina AT jiacao sessileserratedlesionssearchingforthetrueprevalenceandriskfactorsinchina |