D-loop mutations in mitochondrial DNA are a risk factor for chemotherapy resistance in esophageal cancer

D-loop mutations in mitochondrial DNA are a risk factor for chemotherapy resistance in esophageal cancer

Abstract Esophageal cancer is a highly aggressive disease, and acquired resistance to chemotherapy remains a significant hurdle in its treatment. mtDNA, crucial for cellular energy production, is prone to mutations at a higher rate than nuclear DNA. These mutations can accumulate and disrupt cellula...

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Bibliographic Details
Main Authors: Takashi Harino, Koji Tanaka, Daisuke Motooka, Yasunori Masuike, Tsuyoshi Takahashi, Kotaro Yamashita, Takuro Saito, Kazuyoshi Yamamoto, Tomoki Makino, Yukinori Kurokawa, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Esophageal cancer
Mitochondrial DNA
D-loop
Mutation
MtDNA copy number
Chemotherapy
Online Access:https://doi.org/10.1038/s41598-024-80226-3
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