Butyrolactone-I from Marine Fungal Metabolites Mitigates Heat-Stress-Induced Apoptosis in IPEC-J2 Cells and Mice Through the ROS/PERK/CHOP Signaling Pathway

Butyrolactone-I from Marine Fungal Metabolites Mitigates Heat-Stress-Induced Apoptosis in IPEC-J2 Cells and Mice Through the ROS/PERK/CHOP Signaling Pathway

Heat stress poses a significant challenge to animal husbandry, contributing to oxidative stress, intestinal mucosal injury, and apoptosis, which severely impact animal health, growth, and production efficiency. The development of safe, sustainable, and naturally derived solutions to mitigate these e...

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Bibliographic Details
Main Authors: Xueting Niu, Shengwei Chen, Xinchen Wang, Jiaying Wen, Xiaoxi Liu, Yanhong Yong, Zhichao Yu, Xingbing Ma, A. M. Abd El-Aty, Xianghong Ju
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Marine Drugs
Subjects:
Butyrolactone-I (BTL-I)
heat stress
intestinal apoptosis
HSP70 and HSP90 expression
oxidative stress
endoplasmic reticulum stress
Online Access:https://www.mdpi.com/1660-3397/22/12/564
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