Modified PEG-Lipids Enhance the Nasal Mucosal Immune Capacity of Lipid Nanoparticle mRNA Vaccines

Modified PEG-Lipids Enhance the Nasal Mucosal Immune Capacity of Lipid Nanoparticle mRNA Vaccines

Background/Objectives: Omicron, the predominant variant of SARS-CoV-2, exhibits strong immune-evasive properties, leading to the reduced efficacy of existing vaccines. Consequently, the development of versatile vaccines is imperative. Intranasal mRNA vaccines offer convenient administration and have...

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Bibliographic Details
Main Authors: Meng Li, Jing Yi, Yicheng Lu, Ting Liu, Haonan Xing, Xiwei Wang, Hui Zhang, Nan Liu, Zengming Wang, Aiping Zheng
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceutics
Subjects:
chitosan-modified PEGylated lipids
mannose-modified PEGylated lipids
lipid nanoparticles
mucosal immunity
mRNA vaccine
Online Access:https://www.mdpi.com/1999-4923/16/11/1423
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https://www.mdpi.com/1999-4923/16/11/1423

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