Human airway epithelium controls Pseudomonas aeruginosa infection via inducible nitric oxide synthase

Human airway epithelium controls Pseudomonas aeruginosa infection via inducible nitric oxide synthase

IntroductionAirway epithelial cells play a central role in the innate immune response to invading bacteria, yet adequate human infection models are lacking.MethodsWe utilized mucociliary-differentiated human airway organoids with direct access to the apical side of epithelial cells to model the init...

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Main Authors: Philipp Grubwieser, Nina Böck, Erika Kvalem Soto, Richard Hilbe, Patrizia Moser, Markus Seifert, Stefanie Dichtl, Miriam Alisa Govrins, Wilfried Posch, Thomas Sonnweber, Manfred Nairz, Igor Theurl, Zlatko Trajanoski, Günter Weiss
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
airway organoids
Pseudomonas aeruginosa
iNOS
airway epithelia
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1508727/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1508727/full

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