Association of composite dietary antioxidant index with circadian syndrome: evidence from NHANES
BackgroundThe Circadian Syndrome (CircS) has been linked to various chronic diseases. However, the relationship between composite dietary antioxidant index (CDAI) and CircS has remained unexplored. This study aimed to investigate the potential association between CDAI and CircS.MethodsCross-sectiona...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1501352/full |
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| author | Chen Chen Chenyu Zhao Hongyu Jin Zhiping Jiang Wei Wang Wen-Yang Li |
| author_facet | Chen Chen Chenyu Zhao Hongyu Jin Zhiping Jiang Wei Wang Wen-Yang Li |
| author_sort | Chen Chen |
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| description | BackgroundThe Circadian Syndrome (CircS) has been linked to various chronic diseases. However, the relationship between composite dietary antioxidant index (CDAI) and CircS has remained unexplored. This study aimed to investigate the potential association between CDAI and CircS.MethodsCross-sectional analyses were based on the National Health and Nutrition Examination Survey (NHANES) 2005–2018. Dietary consumption was assessed via the 24-h diet recall method and CDAI was computed following a validated approach involving six antioxidants. CircS was defined based on metabolic syndrome components, supplemented by short sleep duration and depressive symptoms. The relationship between CDAI and CircS was examined using weighted multivariable logistic regression and subgroup analyses. Additionally, restricted cubic spline (RCS) regression was employed to investigate potential nonlinear correlations.ResultsAmong 11,048 subjects included (mean age 47.57 years), 2,733 (weighted prevalence = 22.13%) were reported to have CircS. Logistic regression revealed that the highest quartile of CDAI was inversely associated with the risk of CircS {odds ratio (OR) [95% CI = 0.69 (0.55–0.87)]} and the risk of depression [OR = 0.59 (0.48–0.72)], short sleep duration [OR = 0.54 (0.41–0.70)], elevated fasting glucose [OR = 0.80 (0.65–0.98)], elevated triglycerides (TG) [OR = 0.74 (0.59–0.92)], elevated waist circumference [OR = 0.65, (0.52–0.80)] and reduced high-density lipoprotein cholesterol (HDL-C) [OR = 0.75 (0.61–0.92)], respectively. A dose–response gradient in odds of CircS components was noted as CDAI levels increased, particularly with depression and short sleep duration. RCS showed a non-linear relationship between CDAI and CircS, with a U-shaped correlation found between Zinc and CircS (inflection point 12.63). Subgroup analysis showed BMI modified the inverse association between CDAI and CircS (p for interaction = 0.003).ConclusionThis study revealed a non-linear and negative association between CDAI and CircS risk, with a U-shaped correlation observed between Zinc and CircS. Obese individuals might not benefit from excessively high CDAI. The results suggest that a higher CDAI score was correlated with a decreased risk of CircS. |
| format | Article |
| id | doaj-art-f1f7d2c569274c119cdd11906509b687 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-f1f7d2c569274c119cdd11906509b6872025-01-03T12:55:01ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011110.3389/fnut.2024.15013521501352Association of composite dietary antioxidant index with circadian syndrome: evidence from NHANESChen Chen0Chenyu Zhao1Hongyu Jin2Zhiping Jiang3Wei Wang4Wen-Yang Li5Respiratory and Critical Care Department, The First Hospital of China Medical University, Shenyang, ChinaDepartment of China Medical University, School of Pharmacy, The Queen’s University of Belfast Joint College, China Medical University, Shenyang, ChinaRespiratory and Critical Care Department, The First Hospital of China Medical University, Shenyang, ChinaRespiratory and Critical Care Department, The First Hospital of China Medical University, Shenyang, ChinaRespiratory and Critical Care Department, The First Hospital of China Medical University, Shenyang, ChinaRespiratory and Critical Care Department, The First Hospital of China Medical University, Shenyang, ChinaBackgroundThe Circadian Syndrome (CircS) has been linked to various chronic diseases. However, the relationship between composite dietary antioxidant index (CDAI) and CircS has remained unexplored. This study aimed to investigate the potential association between CDAI and CircS.MethodsCross-sectional analyses were based on the National Health and Nutrition Examination Survey (NHANES) 2005–2018. Dietary consumption was assessed via the 24-h diet recall method and CDAI was computed following a validated approach involving six antioxidants. CircS was defined based on metabolic syndrome components, supplemented by short sleep duration and depressive symptoms. The relationship between CDAI and CircS was examined using weighted multivariable logistic regression and subgroup analyses. Additionally, restricted cubic spline (RCS) regression was employed to investigate potential nonlinear correlations.ResultsAmong 11,048 subjects included (mean age 47.57 years), 2,733 (weighted prevalence = 22.13%) were reported to have CircS. Logistic regression revealed that the highest quartile of CDAI was inversely associated with the risk of CircS {odds ratio (OR) [95% CI = 0.69 (0.55–0.87)]} and the risk of depression [OR = 0.59 (0.48–0.72)], short sleep duration [OR = 0.54 (0.41–0.70)], elevated fasting glucose [OR = 0.80 (0.65–0.98)], elevated triglycerides (TG) [OR = 0.74 (0.59–0.92)], elevated waist circumference [OR = 0.65, (0.52–0.80)] and reduced high-density lipoprotein cholesterol (HDL-C) [OR = 0.75 (0.61–0.92)], respectively. A dose–response gradient in odds of CircS components was noted as CDAI levels increased, particularly with depression and short sleep duration. RCS showed a non-linear relationship between CDAI and CircS, with a U-shaped correlation found between Zinc and CircS (inflection point 12.63). Subgroup analysis showed BMI modified the inverse association between CDAI and CircS (p for interaction = 0.003).ConclusionThis study revealed a non-linear and negative association between CDAI and CircS risk, with a U-shaped correlation observed between Zinc and CircS. Obese individuals might not benefit from excessively high CDAI. The results suggest that a higher CDAI score was correlated with a decreased risk of CircS.https://www.frontiersin.org/articles/10.3389/fnut.2024.1501352/fullcomposite dietary antioxidant indexdietary antioxidantcircadian syndromecross-sectional studyNHANESrestricted cubic spline |
| spellingShingle | Chen Chen Chenyu Zhao Hongyu Jin Zhiping Jiang Wei Wang Wen-Yang Li Association of composite dietary antioxidant index with circadian syndrome: evidence from NHANES Frontiers in Nutrition composite dietary antioxidant index dietary antioxidant circadian syndrome cross-sectional study NHANES restricted cubic spline |
| title | Association of composite dietary antioxidant index with circadian syndrome: evidence from NHANES |
| title_full | Association of composite dietary antioxidant index with circadian syndrome: evidence from NHANES |
| title_fullStr | Association of composite dietary antioxidant index with circadian syndrome: evidence from NHANES |
| title_full_unstemmed | Association of composite dietary antioxidant index with circadian syndrome: evidence from NHANES |
| title_short | Association of composite dietary antioxidant index with circadian syndrome: evidence from NHANES |
| title_sort | association of composite dietary antioxidant index with circadian syndrome evidence from nhanes |
| topic | composite dietary antioxidant index dietary antioxidant circadian syndrome cross-sectional study NHANES restricted cubic spline |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1501352/full |
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