ZIKV prM hijacks PIM1 kinase for phosphorylation to prevent ubiquitin−mediated degradation and facilitate viral replication

ZIKV prM hijacks PIM1 kinase for phosphorylation to prevent ubiquitin−mediated degradation and facilitate viral replication

IntroductionViral infection usually stimulates a variety of host cell factors to modulate the life cycle of the virus. PIM1, a serine/threonine protein kinase widely involved in cell proliferation, survival, differentiation and apoptosis, was recently reported to be upregulated by Zika virus (ZIKV)...

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Bibliographic Details
Main Authors: Yingying Ren, Yishuo Liu, Rui Pang, Gang Xu, Yining Lei, Hang Fai Kwok, Yingliang Wu, Zhijian Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
ZIKV
prM
PIM1
phosphorylation
ubiquitination
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1502770/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2024.1502770/full

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