Matrix Architecture and Mechanics Regulate Myofibril Organization, Costamere Assembly, and Contractility in Engineered Myocardial Microtissues

Matrix Architecture and Mechanics Regulate Myofibril Organization, Costamere Assembly, and Contractility in Engineered Myocardial Microtissues

Abstract The mechanical function of the myocardium is defined by cardiomyocyte contractility and the biomechanics of the extracellular matrix (ECM). Understanding this relationship remains an important unmet challenge due to limitations in existing approaches for engineering myocardial tissue. Here,...

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Main Authors: Samuel J. DePalma, Javiera Jilberto, Austin E. Stis, Darcy D. Huang, Jason Lo, Christopher D. Davidson, Aamilah Chowdhury, Robert N. Kent III, Maggie E. Jewett, Hiba Kobeissi, Christopher S. Chen, Emma Lejeune, Adam S. Helms, David A. Nordsletten, Brendon M. Baker
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
biomaterials
cardiac tissue engineering
cardiomyocytes
electrospinning
extracellular matrix
induced pluripotent stem cells
Online Access:https://doi.org/10.1002/advs.202309740
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https://doi.org/10.1002/advs.202309740

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