Double Braking Effects of Nanomedicine on Mitochondrial Permeability Transition Pore for Treating Idiopathic Pulmonary Fibrosis

Double Braking Effects of Nanomedicine on Mitochondrial Permeability Transition Pore for Treating Idiopathic Pulmonary Fibrosis

Abstract Mitochondrial permeability transition pore (mPTP) opening is a key hallmark of injured type II alveolar epithelial cells (AECIIs) in idiopathic pulmonary fibrosis (IPF). Inhibiting mPTP opening in AECIIs is considered a potential IPF treatment. Herein, a “double braking” strategy on mPTP by...

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Main Authors: An Lu, Zhiyi Xu, Zhixia Zhao, Yi Yan, Linxia Jiang, Jing Geng, Hongwei Jin, Xiangyu Wang, Xiaoyan Liu, Yuanjun Zhu, Yujie Shi, Lihong Liu, Huaping Dai, Jian‐Cheng Wang
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
cyclosporin A
idiopathic pulmonary fibrosis
ionizable lipid
lipid nanoparticle
siRNA delivery
Online Access:https://doi.org/10.1002/advs.202405406
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https://doi.org/10.1002/advs.202405406

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