Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes
We have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. At the same time in untreated patients, we obse...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/8487403 |
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| author | Galina A. Dudina Almira D. Donetskova Marina M. Litvina Alexander N. Mitin Tatiana A. Mitina Sergey A. Polyakov |
| author_facet | Galina A. Dudina Almira D. Donetskova Marina M. Litvina Alexander N. Mitin Tatiana A. Mitina Sergey A. Polyakov |
| author_sort | Galina A. Dudina |
| collection | DOAJ |
| description | We have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. At the same time in untreated patients, we observed the shift in the FOXP3 isoforms expression profile towards the full-length molecule possibly due to inflammation. Based on the already known information about the potentially higher functional activity of FOXP3 molecule lacking exon 2, we have also hypothesized that our finding may explain the high risk of autoimmune disorders in this disease. |
| format | Article |
| id | doaj-art-f1119ccab0f5478398f12b83dc56abd0 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-f1119ccab0f5478398f12b83dc56abd02025-02-03T05:47:19ZengWileyAdvances in Hematology1687-91041687-91122018-01-01201810.1155/2018/84874038487403Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic SyndromesGalina A. Dudina0Almira D. Donetskova1Marina M. Litvina2Alexander N. Mitin3Tatiana A. Mitina4Sergey A. Polyakov5Loginov Moscow Clinical Center of the Moscow Health Department, 111123 Moscow, RussiaNational Research Center–Institute of Immunology Federal Medical-Biological Agency of Russia, 115522 Moscow, RussiaNational Research Center–Institute of Immunology Federal Medical-Biological Agency of Russia, 115522 Moscow, RussiaNational Research Center–Institute of Immunology Federal Medical-Biological Agency of Russia, 115522 Moscow, RussiaMoscow Regional Research Clinical Institute Named after MF Vladimirsky, 129110 Moscow, RussiaCelgene International Holdings Corporation, 125047 Moscow, RussiaWe have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. At the same time in untreated patients, we observed the shift in the FOXP3 isoforms expression profile towards the full-length molecule possibly due to inflammation. Based on the already known information about the potentially higher functional activity of FOXP3 molecule lacking exon 2, we have also hypothesized that our finding may explain the high risk of autoimmune disorders in this disease.http://dx.doi.org/10.1155/2018/8487403 |
| spellingShingle | Galina A. Dudina Almira D. Donetskova Marina M. Litvina Alexander N. Mitin Tatiana A. Mitina Sergey A. Polyakov Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes Advances in Hematology |
| title | Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes |
| title_full | Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes |
| title_fullStr | Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes |
| title_full_unstemmed | Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes |
| title_short | Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes |
| title_sort | regulatory t cells and profile of foxp3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes |
| url | http://dx.doi.org/10.1155/2018/8487403 |
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