Machine learning identified novel players in lipid metabolism, endosomal trafficking, and iron metabolism of the ALS spinal cord

Machine learning identified novel players in lipid metabolism, endosomal trafficking, and iron metabolism of the ALS spinal cord

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. Although genes causing familial cases have been identified, those of sporadic ALS, which occupies the majority of patients, are still elusive. In this study, we adopted machine learning to buil...

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Bibliographic Details
Main Authors: Jack Cheng, Bor-Tsang Wu, Hsin-Ping Liu, Wei-Yong Lin
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
ALS
Spinal cord
Machine learning
RNA-seq
Online Access:https://doi.org/10.1038/s41598-024-81315-z
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