Multiple ligands simultaneous molecular docking and dynamics approach to study the synergetic inhibitory of curcumin analogs on ErbB4 tyrosine phosphorylation

Multiple ligands simultaneous molecular docking and dynamics approach to study the synergetic inhibitory of curcumin analogs on ErbB4 tyrosine phosphorylation

Background and purpose: Lapatinib (FMM) and 5-fluorouracil (5-FU) are anticancer drugs employed in a combination approach. FMM inhibits tyrosine phosphorylation of ErbB4 while 5-FU inhibits cell proliferation. This research aimed to investigate the potential of two compounds, namely (1E,4E)-1,5-bis...

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Bibliographic Details
Main Authors: La Ode Aman, Netty Ino Ischak, Teti Sutriyati Tuloli, Arfan Arfan, Aiyi Asnawi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-12-01
Series:Research in Pharmaceutical Sciences
Subjects:
erbb4
simultaneously molecular docking
simultaneously molecular dynamics
Online Access:https://journals.lww.com/10.4103/RPS.RPS_191_23
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https://journals.lww.com/10.4103/RPS.RPS_191_23

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