Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunity
Successful cancer immunotherapy requires novel approaches that overcome intratumoral immunosuppression and peripheral tolerance. In a recent manuscript describing intravenously administered mRNA-loaded lipid particle aggregates (RNA-LPAs), we demonstrate the ability to reprogram both the tumor micro...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2025.2543599 |
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| _version_ | 1849233709068189696 |
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| author | Hector R. Mendez-Gomez John A. Ligon Ashley P. Ghiaseddin Elias J. Sayour |
| author_facet | Hector R. Mendez-Gomez John A. Ligon Ashley P. Ghiaseddin Elias J. Sayour |
| author_sort | Hector R. Mendez-Gomez |
| collection | DOAJ |
| description | Successful cancer immunotherapy requires novel approaches that overcome intratumoral immunosuppression and peripheral tolerance. In a recent manuscript describing intravenously administered mRNA-loaded lipid particle aggregates (RNA-LPAs), we demonstrate the ability to reprogram both the tumor microenvironment and periphery enabling cancer-specific immunity simultaneously generated to compete against immunologically ‘cold’ malignancies like glioblastoma. |
| format | Article |
| id | doaj-art-f0ba26ca79d74d1b8de9042fcd4b9b15 |
| institution | Kabale University |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-f0ba26ca79d74d1b8de9042fcd4b9b152025-08-20T04:03:26ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2543599Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunityHector R. Mendez-Gomez0John A. Ligon1Ashley P. Ghiaseddin2Elias J. Sayour3Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, FL, USADepartment of Pediatrics, Division of Pediatric Hematology-Oncology, University of Florida, Gainesville, FL, USALillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, FL, USALillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, FL, USASuccessful cancer immunotherapy requires novel approaches that overcome intratumoral immunosuppression and peripheral tolerance. In a recent manuscript describing intravenously administered mRNA-loaded lipid particle aggregates (RNA-LPAs), we demonstrate the ability to reprogram both the tumor microenvironment and periphery enabling cancer-specific immunity simultaneously generated to compete against immunologically ‘cold’ malignancies like glioblastoma.https://www.tandfonline.com/doi/10.1080/21645515.2025.2543599mRNA vaccinescancerimmunotherapy |
| spellingShingle | Hector R. Mendez-Gomez John A. Ligon Ashley P. Ghiaseddin Elias J. Sayour Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunity Human Vaccines & Immunotherapeutics mRNA vaccines cancer immunotherapy |
| title | Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunity |
| title_full | Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunity |
| title_fullStr | Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunity |
| title_full_unstemmed | Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunity |
| title_short | Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunity |
| title_sort | systemic mrna aggregates elicit immunologic reprogramming that unlocks anti cancer immunity |
| topic | mRNA vaccines cancer immunotherapy |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2025.2543599 |
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