Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunity

Successful cancer immunotherapy requires novel approaches that overcome intratumoral immunosuppression and peripheral tolerance. In a recent manuscript describing intravenously administered mRNA-loaded lipid particle aggregates (RNA-LPAs), we demonstrate the ability to reprogram both the tumor micro...

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Bibliographic Details
Main Authors: Hector R. Mendez-Gomez, John A. Ligon, Ashley P. Ghiaseddin, Elias J. Sayour
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Human Vaccines & Immunotherapeutics
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Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2025.2543599
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