Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor

Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor

BackgroundBMAL1, a key regulator of circadian rhythms, plays a multifaceted role in brain function. However, the complex interplay between BMAL1, memory, neuroinflammation, and neurotransmitter regulation remains poorly understood. To investigate these interactions, we conducted a study using BMAL1-...

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Bibliographic Details
Main Authors: Weifen Li, Shengnan Mou, Tahir Ali, Tianxiang Li, Yan Liu, Shupeng Li, Xiaoming Yu, Zhi-Jian Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
Bmal1
learning and memory defects
5-HT2CR
neuroinflammation
neurotransmitter
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1422693/full
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