HMGA2/PHGDH axis-mediated glycolysis under hypoxia is required for cadmium-induced A549 cell migration

HMGA2/PHGDH axis-mediated glycolysis under hypoxia is required for cadmium-induced A549 cell migration

Cadmium (Cd) is a widespread environmental contaminant, which has been classified as a human carcinogen. Phosphoglycerate dehydrogenase (PHGDH), the first rate-limiting enzyme involved in the serine biosynthesis pathway, was reported to be able to indicate poor prognosis for cancers. In this study,...

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Bibliographic Details
Main Authors: Chunpeng Gao, Qiuxuan Xie, Li Li, Shengxiang Luo, Jianhui Fan, Jun Cao
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Cadmium
PHGDH
HMGA2
HIF-1α
Glycolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325011327
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