Zoledronate interrupts pre-osteoclast-induced angiogenesis via SDF-1/CXCR4 pathway

Zoledronate interrupts pre-osteoclast-induced angiogenesis via SDF-1/CXCR4 pathway

Introduction: In this study, we tested the hypothesis that pre-osteoclast signaling is key in triggering post-traumatic angiogenesis in alveolar bone via the SDF-1/CXCR4 pathway. Interruption of osteoclast differentiation through zoledronate (Zol) disrupts the crosstalk between pre-osteoclasts and e...

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Main Authors: Mohamed Awad, Elizabeth Taylor-Diaz, Amany Tawfik, Khaled Hussein, Ahmed Elmansi, Mahmoud Elashiry, Ranya Elsayed, Linah Shahoumi, James Borke, William Hill, Fanglong Dong, Mohammed E. Elsalanty
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Bone Reports
Subjects:
Angiogenesis
Osteoclasts
SDF1
CXCR4
Zoledronate
Osteonecrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352187224000792
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