Nuclear N-WASP Induces Actin Polymerization in the Nucleus with Cortactin as an Essential Factor

Nuclear N-WASP Induces Actin Polymerization in the Nucleus with Cortactin as an Essential Factor

Nuclear actin polymerization was reported to control different nuclear processes, but its regulation is poorly understood. Here, we show that N-WASP can trigger the formation of nuclear N-WASP/F-actin nodules. While a cancer hotspot mutant of N-WASP lacking the VCA domain (V418fs) had a dominant neg...

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Bibliographic Details
Main Authors: Xin Jiang, Purusottam Mohapatra, Maria Rossing, Wenqian Zheng, Olga Zbodakova, Jayashree Vijay Thatte, Claus Storgaard Sørensen, Thu Han Le Phan, Cord Brakebusch
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
nuclear F-actin
N-WASP
cortactin
Online Access:https://www.mdpi.com/2073-4409/14/1/59
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