Zebrafish Thrombocytes: Functions and Origins
Platelets play an important role in mammalian hemostasis. Thrombocytes of early vertebrates are functionally equivalent to mammalian platelets. A substantial amount of research has been done to study platelet function in humans as well as in animal models. However, to date only limited functional...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/857058 |
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| author | Gauri Khandekar Seongcheol Kim Pudur Jagadeeswaran |
| author_facet | Gauri Khandekar Seongcheol Kim Pudur Jagadeeswaran |
| author_sort | Gauri Khandekar |
| collection | DOAJ |
| description | Platelets play an important role in mammalian hemostasis. Thrombocytes of early vertebrates are functionally equivalent to mammalian platelets. A substantial amount of research has been done to study platelet function in humans as well as in animal models. However, to date only limited functional genomic studies of platelets have been performed but are low throughput and are not cost-effective. Keeping this in mind we introduced zebrafish, a vertebrate genetic model to study platelet function. We characterized zebrafish thrombocytes and established functional assays study not only their hemostatic function but to also their production. We identified a few genes which play a role in their function and production. Since we introduced the zebrafish model for the study of hemostasis and thrombosis, other groups have adapted this model to study genes that are associated with thrombocyte function and a few novel genes have also been identified. Furthermore, transgenic zebrafish with GFP-tagged thrombocytes have been developed which helped to study the production of thrombocytes and their precursors as well as their functional roles not only in hemostasis but also hematopoiesis. This paper integrates the information available on zebrafish thrombocyte function and its formation. |
| format | Article |
| id | doaj-art-f0569f80480e444eb3679af65e6b7adf |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-f0569f80480e444eb3679af65e6b7adf2025-02-03T05:53:16ZengWileyAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/857058857058Zebrafish Thrombocytes: Functions and OriginsGauri Khandekar0Seongcheol Kim1Pudur Jagadeeswaran2Department of Biological Sciences, University of North Texas, Denton, TX 76203-5017, USADepartment of Biological Sciences, University of North Texas, Denton, TX 76203-5017, USADepartment of Biological Sciences, University of North Texas, Denton, TX 76203-5017, USAPlatelets play an important role in mammalian hemostasis. Thrombocytes of early vertebrates are functionally equivalent to mammalian platelets. A substantial amount of research has been done to study platelet function in humans as well as in animal models. However, to date only limited functional genomic studies of platelets have been performed but are low throughput and are not cost-effective. Keeping this in mind we introduced zebrafish, a vertebrate genetic model to study platelet function. We characterized zebrafish thrombocytes and established functional assays study not only their hemostatic function but to also their production. We identified a few genes which play a role in their function and production. Since we introduced the zebrafish model for the study of hemostasis and thrombosis, other groups have adapted this model to study genes that are associated with thrombocyte function and a few novel genes have also been identified. Furthermore, transgenic zebrafish with GFP-tagged thrombocytes have been developed which helped to study the production of thrombocytes and their precursors as well as their functional roles not only in hemostasis but also hematopoiesis. This paper integrates the information available on zebrafish thrombocyte function and its formation.http://dx.doi.org/10.1155/2012/857058 |
| spellingShingle | Gauri Khandekar Seongcheol Kim Pudur Jagadeeswaran Zebrafish Thrombocytes: Functions and Origins Advances in Hematology |
| title | Zebrafish Thrombocytes: Functions and Origins |
| title_full | Zebrafish Thrombocytes: Functions and Origins |
| title_fullStr | Zebrafish Thrombocytes: Functions and Origins |
| title_full_unstemmed | Zebrafish Thrombocytes: Functions and Origins |
| title_short | Zebrafish Thrombocytes: Functions and Origins |
| title_sort | zebrafish thrombocytes functions and origins |
| url | http://dx.doi.org/10.1155/2012/857058 |
| work_keys_str_mv | AT gaurikhandekar zebrafishthrombocytesfunctionsandorigins AT seongcheolkim zebrafishthrombocytesfunctionsandorigins AT pudurjagadeeswaran zebrafishthrombocytesfunctionsandorigins |