Antimicrobial resistance pattern of clinical isolates in a tertiary care hospital in Sarajevo, Bosnia and Herzegovina
AIM: To determine which resistance to which antibiotic of the isolated bacteria has emerged or increased in order to create a policy for its proper and effective use. BACKGROUND: Antimicrobial resistance (AMR) has emerged as one of the most important public health issues. Over 70% of infections caus...
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Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221371652400198X |
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| author | Tarik Pasagic Sajra Vincevic Smajlovic Amela Dedeic Ljubovic |
| author_facet | Tarik Pasagic Sajra Vincevic Smajlovic Amela Dedeic Ljubovic |
| author_sort | Tarik Pasagic |
| collection | DOAJ |
| description | AIM: To determine which resistance to which antibiotic of the isolated bacteria has emerged or increased in order to create a policy for its proper and effective use. BACKGROUND: Antimicrobial resistance (AMR) has emerged as one of the most important public health issues. Over 70% of infections caused by antibiotic-resistant bacteria are healthcare-associated infections. Resistance to antibiotics used as a last resort in infection therapy, such as carbapenems, has serious consequences for human health. METHODS: This study was conducted from January to December 2023. Standard laboratory procedures were used for isolation and identification. Testing for antibiotic susceptibility was done according to EUCAST guidelines. RESULTS: Out of a total of 2276 Enterobacterales, 895 (39,3%) were extended spectrum beta-lactamases (ESBL) producing. Predominant ESBL-producing isolate was Klebsiella pneumoniae (55,64%) and the highest increase in ESBL-producing isolates was observed in Enterobacter cloacae (12,97%). Out of a total of 1092 Enterobacterales, 281 (25%) were carbapenemase-producing Enterobacterales (CPE). The highest increase in CPE-producing isolates was observed in Klebsiella pneumoniae (11,38%). There was a high rate of resistance to all tested antibiotics for Acinetobacter baumannii (more than 95% isolates were resistant to 6 out of the 9 tested antibiotics) and an increase of 7,61 % in resistance to carbapenems in Pseudomonas aeruginosa. Out of a total of Enterococcus faecium isolates, 103 (44,78%) were Vancomycin-Resistant Enterococci (VRE). CONCLUSION: We can conclude that it is very important that every healthcare institution has an adequate antibiotic resistance monitoring and reporting system in order to prevent horizontal transmission of hospital isolates. |
| format | Article |
| id | doaj-art-f05624a743a54c37a1f399d03930e667 |
| institution | Kabale University |
| issn | 2213-7165 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-f05624a743a54c37a1f399d03930e6672024-12-27T04:08:16ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-12-01398Antimicrobial resistance pattern of clinical isolates in a tertiary care hospital in Sarajevo, Bosnia and HerzegovinaTarik Pasagic0Sajra Vincevic Smajlovic1Amela Dedeic Ljubovic2Clinical Centre of the University of Sarajevo, Unit for Clinical Microbiology, Sarajevo, Bosnia and HerzegovinaClinical Centre of the University of Sarajevo, Unit for Clinical Microbiology, Sarajevo, Bosnia and HerzegovinaClinical Centre of the University of Sarajevo, Unit for Clinical Microbiology, Sarajevo, Bosnia and HerzegovinaAIM: To determine which resistance to which antibiotic of the isolated bacteria has emerged or increased in order to create a policy for its proper and effective use. BACKGROUND: Antimicrobial resistance (AMR) has emerged as one of the most important public health issues. Over 70% of infections caused by antibiotic-resistant bacteria are healthcare-associated infections. Resistance to antibiotics used as a last resort in infection therapy, such as carbapenems, has serious consequences for human health. METHODS: This study was conducted from January to December 2023. Standard laboratory procedures were used for isolation and identification. Testing for antibiotic susceptibility was done according to EUCAST guidelines. RESULTS: Out of a total of 2276 Enterobacterales, 895 (39,3%) were extended spectrum beta-lactamases (ESBL) producing. Predominant ESBL-producing isolate was Klebsiella pneumoniae (55,64%) and the highest increase in ESBL-producing isolates was observed in Enterobacter cloacae (12,97%). Out of a total of 1092 Enterobacterales, 281 (25%) were carbapenemase-producing Enterobacterales (CPE). The highest increase in CPE-producing isolates was observed in Klebsiella pneumoniae (11,38%). There was a high rate of resistance to all tested antibiotics for Acinetobacter baumannii (more than 95% isolates were resistant to 6 out of the 9 tested antibiotics) and an increase of 7,61 % in resistance to carbapenems in Pseudomonas aeruginosa. Out of a total of Enterococcus faecium isolates, 103 (44,78%) were Vancomycin-Resistant Enterococci (VRE). CONCLUSION: We can conclude that it is very important that every healthcare institution has an adequate antibiotic resistance monitoring and reporting system in order to prevent horizontal transmission of hospital isolates.http://www.sciencedirect.com/science/article/pii/S221371652400198Xantimicrobial resistanceextended spectrum beta lactamasecarbapenemase-producing Enterobacteriaceae |
| spellingShingle | Tarik Pasagic Sajra Vincevic Smajlovic Amela Dedeic Ljubovic Antimicrobial resistance pattern of clinical isolates in a tertiary care hospital in Sarajevo, Bosnia and Herzegovina Journal of Global Antimicrobial Resistance antimicrobial resistance extended spectrum beta lactamase carbapenemase-producing Enterobacteriaceae |
| title | Antimicrobial resistance pattern of clinical isolates in a tertiary care hospital in Sarajevo, Bosnia and Herzegovina |
| title_full | Antimicrobial resistance pattern of clinical isolates in a tertiary care hospital in Sarajevo, Bosnia and Herzegovina |
| title_fullStr | Antimicrobial resistance pattern of clinical isolates in a tertiary care hospital in Sarajevo, Bosnia and Herzegovina |
| title_full_unstemmed | Antimicrobial resistance pattern of clinical isolates in a tertiary care hospital in Sarajevo, Bosnia and Herzegovina |
| title_short | Antimicrobial resistance pattern of clinical isolates in a tertiary care hospital in Sarajevo, Bosnia and Herzegovina |
| title_sort | antimicrobial resistance pattern of clinical isolates in a tertiary care hospital in sarajevo bosnia and herzegovina |
| topic | antimicrobial resistance extended spectrum beta lactamase carbapenemase-producing Enterobacteriaceae |
| url | http://www.sciencedirect.com/science/article/pii/S221371652400198X |
| work_keys_str_mv | AT tarikpasagic antimicrobialresistancepatternofclinicalisolatesinatertiarycarehospitalinsarajevobosniaandherzegovina AT sajravincevicsmajlovic antimicrobialresistancepatternofclinicalisolatesinatertiarycarehospitalinsarajevobosniaandherzegovina AT ameladedeicljubovic antimicrobialresistancepatternofclinicalisolatesinatertiarycarehospitalinsarajevobosniaandherzegovina |