Changes in Protein Metabolism and Early Development of Sarcopenia in Mice With Cholestatic Liver Disease

Changes in Protein Metabolism and Early Development of Sarcopenia in Mice With Cholestatic Liver Disease

ABSTRACT Background Sarcopenia is a frequent complication of liver cirrhosis. Here, we chose a mouse model of cholestatic liver disease (CLD) to gain mechanistic insights into the development of sarcopenia from the earliest stages of chronic liver injury. Particular attention was paid to protein met...

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Main Authors: Ottavia Agrifoglio, Solvig Görs, Quentin Sciascia, Zeyang Li, Elke Albrecht, Sophie Achilles, Meike Statz, Manuela Bastian, Tobias Lindner, Karen Friederike Gauß, Sarah Rohde, Karen Rischmüller, Peggy Berlin, Georg Lamprecht, Robert Jaster, Cornelia C. Metges, Luise Ehlers
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
cholestatic liver disease
malnutrition
metabolism
mouse model
sarcopenia
Online Access:https://doi.org/10.1002/jcsm.13737
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https://doi.org/10.1002/jcsm.13737

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