Combinational regenerative inductive effect of bio-adhesive hybrid hydrogels conjugated with hiPSC-derived myofibers and its derived EVs for volumetric muscle regeneration

Combinational regenerative inductive effect of bio-adhesive hybrid hydrogels conjugated with hiPSC-derived myofibers and its derived EVs for volumetric muscle regeneration

In regenerative medicine, extracellular vesicles (EVs) possess the potential to repair injured cells by delivering modulatory factors. However, the therapeutic effect of EVs in large-scale tissue defects, which are subject to prolonged timelines for tissue architecture and functional restoration, re...

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Main Authors: Jiseong Kim, Myung Chul Lee, Jieun Jeon, Alejandra Rodríguez-delaRosa, Yori Endo, Da-Seul Kim, Andrea Donaxi Madrigal-Salazar, Jeong Wook Seo, Hyeseon Lee, Ki-Tae Kim, Jae-I Moon, Seung Gwa Park, Mariana Carolina Lopez-Pacheco, Abdulhameed F. Alkhateeb, Nebras Sobahi, Nicole Bassous, Wenpeng Liu, Jae Seo Lee, Seongsoo Kim, Dilara Yilmaz Aykut, Mahmoud Lotfi Nasr, Mohammad Asif Hussain, Soo-Hong Lee, Woo-Jin Kim, Olivier Pourquié, Indranil Sinha, Su Ryon Shin
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-01-01
Series:Bioactive Materials
Subjects:
Human induced pluripotent stem cells
Extracellular vesicles
Bio-adhesive hydrogel
Muscle regeneration
Volumetric muscle loss
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24004006
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