Synergetic role of TRPV4 inhibitor and mechanical loading on reducing inflammation

Synergetic role of TRPV4 inhibitor and mechanical loading on reducing inflammation

Resolution of inflammation is essential for normal tissue healing and regeneration, with macrophages playing a key role in regulating this process through phenotypic changes from a pro-inflammatory to an anti-inflammatory state. Pharmacological and mechanical (mechanotherapy) techniques can be emplo...

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Bibliographic Details
Main Authors:	Parto Babaniamansour, Diego Jacho, Agustin Rabino, Rafael Garcia-Mata, Eda Yildirim-Ayan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Immunology
Subjects:	transient receptor potential vanilloid 4 (TRPV4) inhibition, mechanical loading macrophage polarization pro-inflammatory (M1) macrophages anti-inflammatory phenotype mitogen-activated protein kinase (MAPK)
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1456042/full
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