Targeted transcriptomic analysis of well-differentiated and dedifferentiated liposarcoma reveals multiple dysregulated pathways including glucose metabolism, TGF-β, and HIF-1 signaling

Targeted transcriptomic analysis of well-differentiated and dedifferentiated liposarcoma reveals multiple dysregulated pathways including glucose metabolism, TGF-β, and HIF-1 signaling

Liposarcoma is the most prevalent sarcoma in adults representing 20% of all sarcomas with well-differentiated/dedifferentiated among the most common subtypes represented. Despite multimodality treatment approaches, there has not been any appreciable change in survival benefit in the past 10 years. T...

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Bibliographic Details
Main Authors: Ashley Patton, Natalie Horn, Puja Upadhaya, Patricia Sarchet, Raphael E. Pollock, Steve Oghumu, Obiajulu Hans Iwenofu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Oncology
Subjects:
dedifferentiated liposarcoma
well-differentiated liposarcoma
NanoString
TGF-β
transcriptome
glucose metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1456071/full
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