Synaptic vesicle characterization of iPSC-derived dopaminergic neurons provides insight into distinct secretory vesicle pools
Abstract The dysfunction of dopaminergic (DA) neurons is central to Parkinson’s disease. Distinct synaptic vesicle (SV) populations, differing in neurotransmitter content (dopamine vs. glutamate), may vary due to differences in trafficking and exocytosis. However, the structural organization of thes...
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Main Authors: | Kenshiro Fujise, Jaya Mishra, Martin Shaun Rosenfeld, Nisha Mohd Rafiq |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2025-01-01
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Series: | npj Parkinson's Disease |
Online Access: | https://doi.org/10.1038/s41531-024-00862-4 |
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