Characteristics of exacerbators in the US Bronchiectasis and NTM Research Registry: a cross-sectional study
Background Exacerbations of noncystic fibrosis bronchiectasis (bronchiectasis) are associated with reduced health-related quality of life and increased mortality, likelihood of hospitalisation and lung function decline. This study investigated patient clinical characteristics associated with exacerb...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2024-11-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/10/6/00185-2024.full |
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| author | Nicole C. Lapinel Radmila Choate Timothy R. Aksamit Joseph Feliciano Kevin L. Winthrop Andreas Schmid Sebastian Fucile Mark L. Metersky |
| author_facet | Nicole C. Lapinel Radmila Choate Timothy R. Aksamit Joseph Feliciano Kevin L. Winthrop Andreas Schmid Sebastian Fucile Mark L. Metersky |
| author_sort | Nicole C. Lapinel |
| collection | DOAJ |
| description | Background
Exacerbations of noncystic fibrosis bronchiectasis (bronchiectasis) are associated with reduced health-related quality of life and increased mortality, likelihood of hospitalisation and lung function decline. This study investigated patient clinical characteristics associated with exacerbation frequency.
Methods
A cross-sectional cohort study of patients ≥18 years with bronchiectasis enrolled in the US Bronchiectasis and Nontuberculous Mycobacteria (NTM) Research Registry (BRR) September 2008–March 2020. Patients were stratified by exacerbation frequency in their 2 years before enrolment. Patient demographics, respiratory symptoms, healthcare resource utilisation, microbiology, modified bronchiectasis severity index (mBSI) and select comorbidities were collected at enrolment. Patient characteristics associated with exacerbation frequency were assessed using a negative binomial model.
Results
The study included 2950 patients (mean age 65.6 years; 79.1% female). Frequency of moderate to severe airway obstruction (forced expiratory volume in 1 s (FEV1) % predicted <50%; most recent measure) was 15.9%, 17.8%, and 24.6% in patients with 1, 2, and ≥3 exacerbations versus 8.9% in patients with 0 exacerbations; severe disease (mBSI) was 27.8%, 24.2% and 51.1% versus 13.2%; respiratory hospitalisation was 24.5%, 33.0% and 36.5% versus 4.1%; and Pseudomonas aeruginosa infection was 18.8%, 23.4% and 35.2% versus 11.9%. In multivariable model analysis, respiratory hospitalisation, cough, haemoptysis, P. aeruginosa, younger age, lower FEV1% predicted, asthma, and gastro-oesophageal reflux disease were associated with more exacerbations.
Conclusions
These findings demonstrate a high disease burden, including increased respiratory symptoms, healthcare resource utilisation, and P. aeruginosa infection in patients with bronchiectasis and multiple exacerbations. |
| format | Article |
| id | doaj-art-efc08f2c9a4d48658ffd18fbfdea0249 |
| institution | Kabale University |
| issn | 2312-0541 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj-art-efc08f2c9a4d48658ffd18fbfdea02492025-01-14T09:50:21ZengEuropean Respiratory SocietyERJ Open Research2312-05412024-11-0110610.1183/23120541.00185-202400185-2024Characteristics of exacerbators in the US Bronchiectasis and NTM Research Registry: a cross-sectional studyNicole C. Lapinel0Radmila Choate1Timothy R. Aksamit2Joseph Feliciano3Kevin L. Winthrop4Andreas Schmid5Sebastian Fucile6Mark L. Metersky7 Northwell Health, New Hyde Park, NY, USA University of Kentucky College of Public Health, Lexington, KY, USA Mayo Clinic, Rochester, MN, USA Insmed Incorporated, Bridgewater, NJ, USA Oregon Health and Science University, Portland, OR, USA University of Kansas Medical Center, Kansas City, KS, USA Insmed Incorporated, Bridgewater, NJ, USA University of Connecticut School of Medicine, Farmington, CT, USA Background Exacerbations of noncystic fibrosis bronchiectasis (bronchiectasis) are associated with reduced health-related quality of life and increased mortality, likelihood of hospitalisation and lung function decline. This study investigated patient clinical characteristics associated with exacerbation frequency. Methods A cross-sectional cohort study of patients ≥18 years with bronchiectasis enrolled in the US Bronchiectasis and Nontuberculous Mycobacteria (NTM) Research Registry (BRR) September 2008–March 2020. Patients were stratified by exacerbation frequency in their 2 years before enrolment. Patient demographics, respiratory symptoms, healthcare resource utilisation, microbiology, modified bronchiectasis severity index (mBSI) and select comorbidities were collected at enrolment. Patient characteristics associated with exacerbation frequency were assessed using a negative binomial model. Results The study included 2950 patients (mean age 65.6 years; 79.1% female). Frequency of moderate to severe airway obstruction (forced expiratory volume in 1 s (FEV1) % predicted <50%; most recent measure) was 15.9%, 17.8%, and 24.6% in patients with 1, 2, and ≥3 exacerbations versus 8.9% in patients with 0 exacerbations; severe disease (mBSI) was 27.8%, 24.2% and 51.1% versus 13.2%; respiratory hospitalisation was 24.5%, 33.0% and 36.5% versus 4.1%; and Pseudomonas aeruginosa infection was 18.8%, 23.4% and 35.2% versus 11.9%. In multivariable model analysis, respiratory hospitalisation, cough, haemoptysis, P. aeruginosa, younger age, lower FEV1% predicted, asthma, and gastro-oesophageal reflux disease were associated with more exacerbations. Conclusions These findings demonstrate a high disease burden, including increased respiratory symptoms, healthcare resource utilisation, and P. aeruginosa infection in patients with bronchiectasis and multiple exacerbations.http://openres.ersjournals.com/content/10/6/00185-2024.full |
| spellingShingle | Nicole C. Lapinel Radmila Choate Timothy R. Aksamit Joseph Feliciano Kevin L. Winthrop Andreas Schmid Sebastian Fucile Mark L. Metersky Characteristics of exacerbators in the US Bronchiectasis and NTM Research Registry: a cross-sectional study ERJ Open Research |
| title | Characteristics of exacerbators in the US Bronchiectasis and NTM Research Registry: a cross-sectional study |
| title_full | Characteristics of exacerbators in the US Bronchiectasis and NTM Research Registry: a cross-sectional study |
| title_fullStr | Characteristics of exacerbators in the US Bronchiectasis and NTM Research Registry: a cross-sectional study |
| title_full_unstemmed | Characteristics of exacerbators in the US Bronchiectasis and NTM Research Registry: a cross-sectional study |
| title_short | Characteristics of exacerbators in the US Bronchiectasis and NTM Research Registry: a cross-sectional study |
| title_sort | characteristics of exacerbators in the us bronchiectasis and ntm research registry a cross sectional study |
| url | http://openres.ersjournals.com/content/10/6/00185-2024.full |
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