SLC1A5 is a key regulator of glutamine metabolism and a prognostic marker for aggressive luminal breast cancer

SLC1A5 is a key regulator of glutamine metabolism and a prognostic marker for aggressive luminal breast cancer

Abstract Cancer cells exhibit altered metabolism, often relying on glutamine (Gln) for growth. Breast cancer (BC) is a heterogeneous disease with varying clinical outcomes. We investigated the role of the amino acid transporter SLC1A5 (ASCT2) and its association with BC subtypes and patient outcomes...

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Bibliographic Details
Main Authors: Lutfi H. Alfarsi, Rokaya El Ansari, Busra Erkan, Ali Fakroun, Madeleine L. Craze, Mohammed A. Aleskandarany, Kiu Wai Cheng, Ian O. Ellis, Emad A. Rakha, Andrew R. Green
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
SLC1A5
Breast cancer
Prognosis
Tumour marker
Online Access:https://doi.org/10.1038/s41598-025-87292-1
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