Deep learning-based radiolabelled compound-protein interaction prediction for NDUFS1-targeting radiopharmaceutical discovery

Deep learning-based radiolabelled compound-protein interaction prediction for NDUFS1-targeting radiopharmaceutical discovery

Abstract Background NDUFS1 is the largest subunit of OXPHOS complex I (MC-I) and mutations in this gene are associated with MC-I deficiency. This study aims to develop a graph neural network and attention mechanism-based radiopharmaceutical-protein (RP-protein) interaction prediction model for ident...

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Bibliographic Details
Main Authors: Muath Almaslamani, Jingyu Yang, Chi Soo Kang, Choong Mo Kang, Jung Mi Park, Sang-Keun Woo
Format: Article
Language:English
Published: SpringerOpen 2025-08-01
Series:EJNMMI Research
Subjects:
Binding affinity
Radiopharmaceutical discovery
Compound protein interaction
Graph neural network
Mitochondria
NDUFS1
Online Access:https://doi.org/10.1186/s13550-025-01300-z
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https://doi.org/10.1186/s13550-025-01300-z

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