Integrated transcriptomics and metabolomics studies reveal the therapeutic effects of Astragalus polysaccharides on cancer cachexia muscle atrophy

Integrated transcriptomics and metabolomics studies reveal the therapeutic effects of Astragalus polysaccharides on cancer cachexia muscle atrophy

Abstract Cancer cachexia (CC) is a condition causing significant muscle loss in advanced cancer patients, severely impacting their quality of life and life expectancy. The autophagy–lysosome system is a key pathway in muscle depletion in CC, but targeted therapies are lacking. This study investigate...

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Bibliographic Details
Main Authors: Zhihan Tian, Yong Wang, Xue Liu, Xin Xin, Shuai Liu, Yiwei Qu, Ziyuan Li, Xiaoyu Su, Dufang Ma
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Transcriptomics
Metabolomics
Astragalus polysaccharides
Cancer cachexia
Muscle atrophy
Autophagy
Online Access:https://doi.org/10.1038/s41598-025-11342-x
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