Capgras syndrome, an interesting but rare phenomenon in Psychiatry: A case series

Capgras syndrome is one of the delusional misidentification syndromes, where the patient believes that a familiar person, particularly a loved one, has been replaced by an imposter or a double, and is a rare entity in clinical practice. Although the phenomenon is known to occur as a part of other ps...

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Main Authors: Arghya Halder, Sagarika Ray, Manish Kumar, Amit Kumar Bhattacharya
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-12-01
Series:Telangana Journal of Psychiatry
Subjects:
Online Access:https://journals.lww.com/10.4103/tjp.tjp_21_24
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author Arghya Halder
Sagarika Ray
Manish Kumar
Amit Kumar Bhattacharya
author_facet Arghya Halder
Sagarika Ray
Manish Kumar
Amit Kumar Bhattacharya
author_sort Arghya Halder
collection DOAJ
description Capgras syndrome is one of the delusional misidentification syndromes, where the patient believes that a familiar person, particularly a loved one, has been replaced by an imposter or a double, and is a rare entity in clinical practice. Although the phenomenon is known to occur as a part of other psychiatric disorders such as schizophrenia and mood disorders, it is not infrequently encountered in organic conditions such as cerebrovascular disease, dementia, and epilepsy. Thus, it is important to rule out any underlying organic etiology by the use of appropriate neuroimaging techniques whenever felt necessary. There are no clear-cut guidelines regarding the treatment of this condition, but atypical antipsychotics seem to be the first-line agents. In this article, we have described three cases, who presented with Capgras syndrome, in association with various other psychiatric diagnoses, such as cannabis-induced psychosis, recurrent depressive disorder, currently severe depressive episode with psychotic symptoms, and schizophrenia. All the cases responded well after treatment with olanzapine, with complete resolution of Capgras delusions in the first two cases, and partial response in the third case, where there was a reduction in the level of conviction of Capgras delusions, and marked improvement in overall functioning. Thus, olanzapine could be a reasonable choice in treating Capgras syndrome in patient populations where there are no contraindications to prescribe this drug.
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publisher Wolters Kluwer Medknow Publications
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series Telangana Journal of Psychiatry
spelling doaj-art-eeb9f6a3b14640e7b48410b6de0f43192025-01-07T10:02:21ZengWolters Kluwer Medknow PublicationsTelangana Journal of Psychiatry2772-87062455-85592024-12-0110218318710.4103/tjp.tjp_21_24Capgras syndrome, an interesting but rare phenomenon in Psychiatry: A case seriesArghya HalderSagarika RayManish KumarAmit Kumar BhattacharyaCapgras syndrome is one of the delusional misidentification syndromes, where the patient believes that a familiar person, particularly a loved one, has been replaced by an imposter or a double, and is a rare entity in clinical practice. Although the phenomenon is known to occur as a part of other psychiatric disorders such as schizophrenia and mood disorders, it is not infrequently encountered in organic conditions such as cerebrovascular disease, dementia, and epilepsy. Thus, it is important to rule out any underlying organic etiology by the use of appropriate neuroimaging techniques whenever felt necessary. There are no clear-cut guidelines regarding the treatment of this condition, but atypical antipsychotics seem to be the first-line agents. In this article, we have described three cases, who presented with Capgras syndrome, in association with various other psychiatric diagnoses, such as cannabis-induced psychosis, recurrent depressive disorder, currently severe depressive episode with psychotic symptoms, and schizophrenia. All the cases responded well after treatment with olanzapine, with complete resolution of Capgras delusions in the first two cases, and partial response in the third case, where there was a reduction in the level of conviction of Capgras delusions, and marked improvement in overall functioning. Thus, olanzapine could be a reasonable choice in treating Capgras syndrome in patient populations where there are no contraindications to prescribe this drug.https://journals.lww.com/10.4103/tjp.tjp_21_24capgrasdelusional misidentification syndromeolanzapineorganicpsychosis
spellingShingle Arghya Halder
Sagarika Ray
Manish Kumar
Amit Kumar Bhattacharya
Capgras syndrome, an interesting but rare phenomenon in Psychiatry: A case series
Telangana Journal of Psychiatry
capgras
delusional misidentification syndrome
olanzapine
organic
psychosis
title Capgras syndrome, an interesting but rare phenomenon in Psychiatry: A case series
title_full Capgras syndrome, an interesting but rare phenomenon in Psychiatry: A case series
title_fullStr Capgras syndrome, an interesting but rare phenomenon in Psychiatry: A case series
title_full_unstemmed Capgras syndrome, an interesting but rare phenomenon in Psychiatry: A case series
title_short Capgras syndrome, an interesting but rare phenomenon in Psychiatry: A case series
title_sort capgras syndrome an interesting but rare phenomenon in psychiatry a case series
topic capgras
delusional misidentification syndrome
olanzapine
organic
psychosis
url https://journals.lww.com/10.4103/tjp.tjp_21_24
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AT sagarikaray capgrassyndromeaninterestingbutrarephenomenoninpsychiatryacaseseries
AT manishkumar capgrassyndromeaninterestingbutrarephenomenoninpsychiatryacaseseries
AT amitkumarbhattacharya capgrassyndromeaninterestingbutrarephenomenoninpsychiatryacaseseries