Effect of the TAAR1 Partial Agonist Ralmitaront on Presynaptic Dopamine Synthesis Capacity Measured Using [F]DOPA PET in Naïve and Cocaine-Treated Mice

Effect of the TAAR1 Partial Agonist Ralmitaront on Presynaptic Dopamine Synthesis Capacity Measured Using [F]DOPA PET in Naïve and Cocaine-Treated Mice

Purpose Elevated dopamine synthesis capacity is part of the pathophysiology of schizophrenia thought to underlie psychosis. Drugs that reduce this phenomenon could thus be potential treatments for these disorders. In this study, we evaluated the ability of the trace amine-associated receptor 1 (TAAR...

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Main Authors: David R. Bonsall PhD, Michelle Kokkinou PhD, Els F. Halff PhD, Grazia Rutigliano PhD, Sac-Pham Tang MSc, Mattia Veronese PhD, Elaine E. Irvine PhD, Dominic J. Withers FRCP, PhD, Lisa A. Wells PhD, Sridhar Natesan PhD, Irene Gerlach PhD, Štefan Holiga PhD, Marius C. Hoener PhD, Oliver D. Howes MRCpsych, PhD
Format: Article
Language:English
Published: SAGE Publications 2024-12-01
Series:Molecular Imaging
Online Access:https://doi.org/10.1177/15353508241299546
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https://doi.org/10.1177/15353508241299546

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