The inactivation of the Niemann Pick C1 cholesterol transporter restricts SARS-CoV-2 entry into host cells by decreasing ACE2 abundance at the plasma membrane

The inactivation of the Niemann Pick C1 cholesterol transporter restricts SARS-CoV-2 entry into host cells by decreasing ACE2 abundance at the plasma membrane

Abstract Background The Niemann Pick C1 (NPC1) protein is an intracellular cholesterol transporter located in the late endosome/lysosome (LE/Ly) that is involved in the mobilization of endocytosed cholesterol. Loss-of-function mutations in the NPC1 gene lead to the accumulation of cholesterol and sp...

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Bibliographic Details
Main Authors: Piergiorgio La Rosa, Jessica Tiberi, Enrico Palermo, Roberta Stefanelli, Sofia Maria Luigia Tiano, Sonia Canterini, Mirko Cortese, John Hiscott, Maria Teresa Fiorenza
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell & Bioscience
Subjects:
Spike-ACE2 interaction
ACE2
Virus entry
Lipid dyshomeostasis
Online Access:https://doi.org/10.1186/s13578-024-01331-4
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https://doi.org/10.1186/s13578-024-01331-4

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