LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

Abstract Skeletal muscle plays a crucial role in maintaining motor function and metabolic homeostasis, with its loss or atrophy leading to significant health consequences. Long non‐coding RNAs (lncRNAs) have emerged as key regulators in muscle biology; however, their precise roles in muscle function...

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Main Authors: Yilong Yao, Chao Yan, Haibo Huang, Shilong Wang, Jiaying Li, Yun Chen, Xiaolu Qu, Qi Bao, Lingna Xu, Yuanyuan Zhang, Danyang Fan, Xia He, Yanwen Liu, Yongsheng Zhang, Yalan Yang, Zhonglin Tang
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
fat infiltration
lncRNA‐MEG3
muscle atrophy
oxidative muscle fibers
SUZ12 LLPS
Online Access:https://doi.org/10.1002/advs.202417715
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https://doi.org/10.1002/advs.202417715

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