Self-powered triboelectric-responsive microneedles with controllable release of optogenetically engineered extracellular vesicles for intervertebral disc degeneration repair

Self-powered triboelectric-responsive microneedles with controllable release of optogenetically engineered extracellular vesicles for intervertebral disc degeneration repair

Abstract Excessive exercise is an etiological factor of intervertebral disc degeneration (IVDD). Engineered extracellular vesicles (EVs) exhibit excellent therapeutic potential for disease-modifying treatments. Herein, we fabricate an exercise self-powered triboelectric-responsive microneedle (MN) a...

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Main Authors: Weifeng Zhang, Xuan Qin, Gaocai Li, Xingyu Zhou, Hongyang Li, Di Wu, Yu Song, Kangcheng Zhao, Kun Wang, Xiaobo Feng, Lei Tan, Bingjin Wang, Xuhui Sun, Zhen Wen, Cao Yang
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-50045-1
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https://doi.org/10.1038/s41467-024-50045-1

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