Screening of ent-copalyl diphosphate synthase and metabolic engineering to achieve de novo biosynthesis of ent-copalol in Saccharomyces cerevisiae

Screening of ent-copalyl diphosphate synthase and metabolic engineering to achieve de novo biosynthesis of ent-copalol in Saccharomyces cerevisiae

The diterpene ent-copalol is an important precursor to the synthesis of andrographolide and is found only in green chiretta (Andrographis paniculata). De novo biosynthesis of ent-copalol has not been reported, because the catalytic activity of ent-copalyl diphosphate synthase (CPS) is very low in mi...

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Bibliographic Details
Main Authors: Shan Li, Shuangshuang Luo, Xinran Yin, Xingying Zhao, Xuyang Wang, Song Gao, Sha Xu, Jian Lu, Jingwen Zhou
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-12-01
Series:Synthetic and Systems Biotechnology
Subjects:
Andrographis paniculata
Ent-copalyl diphosphate synthase
ent-CPP
Diterpene synthase
Acetyl-CoA
Quantification
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X24000942
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http://www.sciencedirect.com/science/article/pii/S2405805X24000942

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