Development of multi-epitope mRNA vaccine against Clostridioides difficile using reverse vaccinology and immunoinformatics approaches

Development of multi-epitope mRNA vaccine against Clostridioides difficile using reverse vaccinology and immunoinformatics approaches

Clostridioides difficile (C. difficile), as the major pathogen of diarrhea in healthcare settings, has become increasingly prevalent within community populations, resulting in significant morbidity and mortality. However, the therapeutic options for Clostridioides difficile infection (CDI) remain li...

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Bibliographic Details
Main Authors: Caixia Tan, Yuanyuan xiao, Ting Liu, Siyao Chen, Juan Zhou, Sisi Zhang, Yiran Hu, Anhua Wu, Chunhui Li
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-12-01
Series:Synthetic and Systems Biotechnology
Subjects:
Clotridioides difficile (C. difficile)
mRNA vaccine
Immunoinformatics
Reverse vaccinology (RV)
Molecular docking
Molecular dynamics (MD) simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X24000838
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