ABL1‒YAP1 axis in intestinal stem cell activated by deoxycholic acid contributes to hepatic steatosis

ABL1‒YAP1 axis in intestinal stem cell activated by deoxycholic acid contributes to hepatic steatosis

Abstract Background Yes-associated protein 1 (YAP1) regulates the survival, proliferation, and stemness of cells, and contributes to the development of metabolic dysfunction associated fatty liver disease (MAFLD). However, the regulatory role of intestinal YAP1 in MAFLD still remains unclear. Method...

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Bibliographic Details
Main Authors: Tiancheng Mao, Xianjun Xu, Leheng Liu, Yulun Wu, Xiaowan Wu, Wenlu Niu, Dandan You, Xiaobo Cai, Lungen Lu, Hui Zhou
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
Yes-associated protein 1
Deoxycholic acid
High-fat diet
Intestinal stem cell
Hepatic steatosis
Online Access:https://doi.org/10.1186/s12967-024-05865-6
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https://doi.org/10.1186/s12967-024-05865-6

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