Structure of a Cyclic Peptide as an Inhibitor of <i>Mycobacterium tuberculosis</i> Transcription: NMR and Molecular Dynamics Simulations
Background and Objectives: A novel antitubercular cyclic peptide, Cyclo(1,6)-Ac-CLYHFC-NH<sub>2</sub>, was designed to bind at the rifampicin (RIF) binding site on the RNA polymerase (RNAP) of <i>Mycobacterium tuberculosis</i> (MTB). This peptide inhibits RNA elongation in th...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/17/11/1545 |
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