Integrated bioinformatics and experimental validation identify lysosome and immune infiltration-related genes as therapeutic targets in late-onset major depressive disorder

Integrated bioinformatics and experimental validation identify lysosome and immune infiltration-related genes as therapeutic targets in late-onset major depressive disorder

Abstract This study leverages bioinformatics to identify differential genes linked to lysosomal alterations in late-onset major depressivedisorder (LOD) patients and explores potential therapeutic drugs. We analyzed differential genes in the GSE76826 dataset usingWGCNA to identify modules associated...

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Bibliographic Details
Main Authors: Jian-Zhen Hu, Yao Gao, Xiao-Na Song, Dan Wang, Xin-Zhe Du, Xiao Wang, Xiao-Dong Hu, Sha Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Biological information
Late-onset major depressive disorder
CD8 + T cells
Regression analysis
Immune infiltration
Online Access:https://doi.org/10.1038/s41598-025-10283-9
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https://doi.org/10.1038/s41598-025-10283-9

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