Network pharmacology analyses and corresponding validation of the mechanistic effects of Yangyin Tongnao Granules in ischemic stroke

Network pharmacology analyses and corresponding validation of the mechanistic effects of Yangyin Tongnao Granules in ischemic stroke

Abstract Yangyin Tongnao Granules (YYTN) is a traditional Chinese medicinal prescription that has been proposed to offer value as a treatment for ischemic stroke (IS). The mechanistic basis for its function, however, remains to be established. This study investigates the molecular mechanism of YYTN...

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Bibliographic Details
Main Authors: Jiaying Yu, Qianqian Chen, Xiaotong Dou, Rongjin Zhu, Jiehong Yang, Weifeng Jin, Haitong Wan, Li Yu, Yangyang Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Ischemic stroke
Yangyin Tongnao Granules
Network pharmacology
Molecular docking
Experimental validation
HIF-1 signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-10292-8
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https://doi.org/10.1038/s41598-025-10292-8

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