Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer

Tumor-derived microvesicles (TD-MVs) are key mediators which are shed by cancer cells and can sensitize neighboring cells in the tumor microenvironment. TD-MVs are extracellular vesicles composed of exosomes and MVs and promote cancer invasion and metastasis. Intratumoral hypoxia is an integral comp...

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Bibliographic Details
Main Authors: Guy Berchem, Muhammad Zaeem Noman, Manon Bosseler, Jerome Paggetti, Sonia Baconnais, Eric Le cam, Arash Nanbakhsh, Etienne Moussay, Fathia Mami-Chouaib, Bassam Janji, Salem Chouaib
Format: Article
Language:English
Published: Taylor & Francis Group 2016-04-01
Series:OncoImmunology
Subjects:
Hypoxia
LAMP-1
microvesicles
miR-23a
natural killer cells
NKG2D
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2015.1062968
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https://www.tandfonline.com/doi/10.1080/2162402X.2015.1062968

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