Divergent B-cell repertoire remodelling by mRNA, DNA and live attenuated vaccines in fish

Divergent B-cell repertoire remodelling by mRNA, DNA and live attenuated vaccines in fish

Abstract Vaccination is critical for the future of aquaculture, and nucleic acid vaccines have a major potential for fighting emerging fish infectious diseases, yet their mechanisms remain poorly understood. We compared B-cell responses induced by an mRNA, a DNA, and an attenuated vaccine, all encod...

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Main Authors: Dean Porter, Catherine Collins, Andrea Mazzolini, Luc Jouneau, Vanessa Mhanna, Céline Coiffier, Mathilde Peruzzi, Yan Jaszczyszyn, Encarnita Mariotti-Ferrandiz, Francois Huetz, Bertrand Collet, Thierry Mora, Aleksandra M. Walczak, Bernard Verrier, Pierre Boudinot
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01232-8
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https://doi.org/10.1038/s41541-025-01232-8

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