MYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition

MYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition

Summary: Human N-myristoyltransferases (NMTs) catalyze N-terminal protein N-myristoylation and are promising targets in cancer, with an emerging mechanistic rationale for targeted therapy. Here, we screened 245 cancer cell lines against IMP-1320, a potent NMT inhibitor (NMTi), and conducted pathway-...

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Main Authors: Gregor A. Lueg, James Zhang, Monica Faronato, Andrii Gorelik, Wouter W. Kallemeijn, Francesco Falciani, Josephine Walton, Jack W. Houghton, Silvia Vannini, Evon Poon, Barbara M. Costa, Roberto Solari, Robin Carr, Andrew S. Bell, Edward J. Bartlett, Bernadette Brzezicha, Martin Janz, Louis Chesler, Dinis P. Calado, Edward W. Tate
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725009519
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http://www.sciencedirect.com/science/article/pii/S2211124725009519

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