When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis

When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis

<b>Introduction:</b> Here we consider the collision of a genetic factor and an essential instigator in Alzheimer’s neuropathogenesis: (i) the Alzheimer’s gene (APOEε4), which downregulates lysosomal autophagy and induces synthesis of (ii) the instigator, interleukin-1β (IL-1β), which dri...

Full description

Saved in:
Bibliographic Details
Main Authors: Jagadeesh Narasimhappagari, Ling Liu, Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, W. Sue T. Griffin
Format: Article
Language:English
Published: MDPI AG 2025-08-01
Series:Cells
Subjects:
APOEε4
Interleukin-1β
Neuroinflammation
autophagy
Online Access:https://www.mdpi.com/2073-4409/14/15/1216
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2073-4409/14/15/1216

Similar Items