Melanoma in pregnancy: multidisciplinary treatment management and outcome
Pregnancy-associated melanoma affects both maternal and fetal health. This study aims to demonstrate how a specialized center and a multidisciplinary approach can provide the best outcomes. From January 2006 to September 2023, a bicentric observational study was conducted at the Plastic Surgery Dep...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2025-01-01
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| Series: | Dermatology Reports |
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| Online Access: | https://www.pagepress.org/journals/dr/article/view/10095 |
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| author | Francesca Romana Grippaudo Giulia Ruggeri Paola De Simone Monia Di Prete Guglielmo Tellan Elena Rita Govoni Emilia Migliano |
| author_facet | Francesca Romana Grippaudo Giulia Ruggeri Paola De Simone Monia Di Prete Guglielmo Tellan Elena Rita Govoni Emilia Migliano |
| author_sort | Francesca Romana Grippaudo |
| collection | DOAJ |
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Pregnancy-associated melanoma affects both maternal and fetal health. This study aims to demonstrate how a specialized center and a multidisciplinary approach can provide the best outcomes. From January 2006 to September 2023, a bicentric observational study was conducted at the Plastic Surgery Department of Policlinico Umberto I, Sapienza University of Rome, and at the Plastic and Regenerative Surgery Department of the San Gallicano Dermatological Institute IRCCS, Rome, Italy. Out of 6800 melanoma cases, twenty pregnant women were selected: thirteen underwent only wide local excision (WLE), while seven also had sentinel node biopsy (SLNB). All preoperative, operative, and postoperative steps were performed to ensure the safety of mothers and fetuses. Two patients developed metastases, with one fatality from hepatic metastases. The overall survival rate at 5-year follow-up was 86%, and 72% for advanced stages and disease-free patients. No maternal or fetal complications related to surgery were reported. Additionally, early deliveries at 7 and 8 months did not result in neonatal complications. Surgical treatment should be conducted in centers with both surgeons and gynecologists, and special care is necessary for procedures on pregnant women. Based on our experience, pregnancy does not seem to be a negative prognostic factor for melanoma.
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| format | Article |
| id | doaj-art-eb7a6fb2b1bb4e26ba6268126fba9f30 |
| institution | Kabale University |
| issn | 2036-7392 2036-7406 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj-art-eb7a6fb2b1bb4e26ba6268126fba9f302025-01-16T01:42:29ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062025-01-0110.4081/dr.2025.10095Melanoma in pregnancy: multidisciplinary treatment management and outcomeFrancesca Romana Grippaudo0Giulia Ruggeri1Paola De Simone2Monia Di Prete3Guglielmo Tellan4Elena Rita Govoni5Emilia Migliano6Department of Plastic Surgery, Policlinico Umberto I, Sapienza University of RomeDepartment of Plastic Surgery, Policlinico Umberto I, Sapienza University of RomeDermatological Oncology, San Gallicano Dermatological Institute IRCCS (ISG), RomeDermatopathology Unit, San Gallicano Dermatological Institute IRCCS (ISG), RomeDepartment of Internistic, Anaesthetic and Cardiovascular Clinical Sciences, Sapienza University of RomeMedicine and Surgery, Campus Bio-medico University of RomePlastic and Regenerative Surgery Department, San Gallicano Dermatological Institute IRCCS (ISG), Rome Pregnancy-associated melanoma affects both maternal and fetal health. This study aims to demonstrate how a specialized center and a multidisciplinary approach can provide the best outcomes. From January 2006 to September 2023, a bicentric observational study was conducted at the Plastic Surgery Department of Policlinico Umberto I, Sapienza University of Rome, and at the Plastic and Regenerative Surgery Department of the San Gallicano Dermatological Institute IRCCS, Rome, Italy. Out of 6800 melanoma cases, twenty pregnant women were selected: thirteen underwent only wide local excision (WLE), while seven also had sentinel node biopsy (SLNB). All preoperative, operative, and postoperative steps were performed to ensure the safety of mothers and fetuses. Two patients developed metastases, with one fatality from hepatic metastases. The overall survival rate at 5-year follow-up was 86%, and 72% for advanced stages and disease-free patients. No maternal or fetal complications related to surgery were reported. Additionally, early deliveries at 7 and 8 months did not result in neonatal complications. Surgical treatment should be conducted in centers with both surgeons and gynecologists, and special care is necessary for procedures on pregnant women. Based on our experience, pregnancy does not seem to be a negative prognostic factor for melanoma. https://www.pagepress.org/journals/dr/article/view/10095Melanomapregnancyskin cancersentinel lymph node biopsysurvival |
| spellingShingle | Francesca Romana Grippaudo Giulia Ruggeri Paola De Simone Monia Di Prete Guglielmo Tellan Elena Rita Govoni Emilia Migliano Melanoma in pregnancy: multidisciplinary treatment management and outcome Dermatology Reports Melanoma pregnancy skin cancer sentinel lymph node biopsy survival |
| title | Melanoma in pregnancy: multidisciplinary treatment management and outcome |
| title_full | Melanoma in pregnancy: multidisciplinary treatment management and outcome |
| title_fullStr | Melanoma in pregnancy: multidisciplinary treatment management and outcome |
| title_full_unstemmed | Melanoma in pregnancy: multidisciplinary treatment management and outcome |
| title_short | Melanoma in pregnancy: multidisciplinary treatment management and outcome |
| title_sort | melanoma in pregnancy multidisciplinary treatment management and outcome |
| topic | Melanoma pregnancy skin cancer sentinel lymph node biopsy survival |
| url | https://www.pagepress.org/journals/dr/article/view/10095 |
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