Amitriptyline potently neutralizes distinct SARS-CoV-2 variants including D614G, Omicron BA.5, and Omicron XBB.1

Amitriptyline potently neutralizes distinct SARS-CoV-2 variants including D614G, Omicron BA.5, and Omicron XBB.1

IntroductionCOVID-19, caused by SARS-CoV-2, remains a global health challenge despite the availability of vaccines and antiviral treatments. The emergence of immune escape variants and the persistence of long COVID symptoms continue to complicate prevention and therapy, especially in low-resource se...

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Main Authors: Isabel Zydek, Laura Thümmler, Nadine Beckmann, Carolin Sehl, Matthias Soddemann, Rabea Grüneberg, Carina Elsner, Markus Kamler, Ulf Dittmer, Oliver Witzke, Stephanie Kadow, Erich Gulbins, Katrin Anne Becker, Adalbert Krawczyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Microbiology
Subjects:
SARS-CoV-2
antidepressants
amitriptyline
COVID-19
FIASMA
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1631947/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1631947/full

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