Combined inhibition of histone methyltransferases EZH2 and DOT1L is an effective therapy for neuroblastoma

Combined inhibition of histone methyltransferases EZH2 and DOT1L is an effective therapy for neuroblastoma

Abstract Background The child cancer, neuroblastoma (NB), is characterised by a low incidence of mutations and strong oncogenic embryonal driver signals. Many new targeted epigenetic modifier drugs have failed in human trials as monotherapy. Methods We performed a high‐throughput, combination chroma...

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Main Authors: Janith A. Seneviratne, Daenikka Ravindrarajah, Daniel R. Carter, Vicki Zhai, Amit Lalwani, Sukriti Krishan, Anushree Balachandran, Ernest Ng, Ruby Pandher, Matthew Wong, Tracy L. Nero, Shudong Wang, Murray D. Norris, Michelle Haber, Tao Liu, Michael W. Parker, Belamy B. Cheung, Glenn M. Marshall
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Cancer Medicine
Subjects:
biomarkers
cancer biology
chromatin modifications and dynamics
epigenetics
molecular biology
neuroblastoma
Online Access:https://doi.org/10.1002/cam4.70082
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https://doi.org/10.1002/cam4.70082

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