Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature
Abstract Non-invasive, low intensity focused ultrasound is an emerging neuromodulation technique that offers the potential for precision, personalized therapy. An increasing body of research has identified mechanosensitive ion channels that can be modulated by FUS and support acute electrical activi...
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| Format: | Article |
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Nature Portfolio
2025-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07356-2 |
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| author | YuBing Y. Shen Jyoti V. Jethe Ashlan P. Reid Jacob Hehir Marcello Magri Amaral Chao Ren Senyue Hao Chao Zhou Jonathan A. N. Fisher |
| author_facet | YuBing Y. Shen Jyoti V. Jethe Ashlan P. Reid Jacob Hehir Marcello Magri Amaral Chao Ren Senyue Hao Chao Zhou Jonathan A. N. Fisher |
| author_sort | YuBing Y. Shen |
| collection | DOAJ |
| description | Abstract Non-invasive, low intensity focused ultrasound is an emerging neuromodulation technique that offers the potential for precision, personalized therapy. An increasing body of research has identified mechanosensitive ion channels that can be modulated by FUS and support acute electrical activity in neurons. However, neuromodulatory effects that persist from hours to days have also been reported. The brain’s ability to provide blood flow to electrically active regions involves a multitude of non-neuronal cell types and signaling pathways in the cerebral vasculature; an open question is whether persistent effects can be attributed, at least partly, to vascular mechanisms. Using an in vivo optical approach, we found that microvasculature, and not larger vessels, exhibit significant persistent dilation following sonication without the use of microbubbles. This finding reveals a heretofore unseen aspect of the effects of FUS in vivo and indicates that concurrent changes in neurovascular function may partially underly persistent neuromodulatory effects. |
| format | Article |
| id | doaj-art-eae12245914549eda0523826a68421bc |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-eae12245914549eda0523826a68421bc2025-01-12T12:35:47ZengNature PortfolioCommunications Biology2399-36422025-01-018111110.1038/s42003-024-07356-2Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculatureYuBing Y. Shen0Jyoti V. Jethe1Ashlan P. Reid2Jacob Hehir3Marcello Magri Amaral4Chao Ren5Senyue Hao6Chao Zhou7Jonathan A. N. Fisher8Department of Physiology, New York Medical CollegeDepartment of Physiology, New York Medical CollegeDepartment of Physiology, New York Medical CollegeDepartment of Physiology, New York Medical CollegeDepartment of Biomedical Engineering, Washington University in St LouisImaging Science Ph.D. Program, Washington University in St LouisDepartment of Electrical & Systems Engineering, Washington University in St LouisDepartment of Biomedical Engineering, Washington University in St LouisDepartment of Physiology, New York Medical CollegeAbstract Non-invasive, low intensity focused ultrasound is an emerging neuromodulation technique that offers the potential for precision, personalized therapy. An increasing body of research has identified mechanosensitive ion channels that can be modulated by FUS and support acute electrical activity in neurons. However, neuromodulatory effects that persist from hours to days have also been reported. The brain’s ability to provide blood flow to electrically active regions involves a multitude of non-neuronal cell types and signaling pathways in the cerebral vasculature; an open question is whether persistent effects can be attributed, at least partly, to vascular mechanisms. Using an in vivo optical approach, we found that microvasculature, and not larger vessels, exhibit significant persistent dilation following sonication without the use of microbubbles. This finding reveals a heretofore unseen aspect of the effects of FUS in vivo and indicates that concurrent changes in neurovascular function may partially underly persistent neuromodulatory effects.https://doi.org/10.1038/s42003-024-07356-2 |
| spellingShingle | YuBing Y. Shen Jyoti V. Jethe Ashlan P. Reid Jacob Hehir Marcello Magri Amaral Chao Ren Senyue Hao Chao Zhou Jonathan A. N. Fisher Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature Communications Biology |
| title | Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature |
| title_full | Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature |
| title_fullStr | Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature |
| title_full_unstemmed | Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature |
| title_short | Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature |
| title_sort | label free capillary scale blood flow mapping in vivo reveals that low intensity focused ultrasound evokes persistent dilation in cortical microvasculature |
| url | https://doi.org/10.1038/s42003-024-07356-2 |
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