Carbapenem-resistant Klebsiella pneumoniae in COVID-19 patients admitted to intensive care units of Zagazig University Hospitals
Background: Continuous monitoring is crucial to detect infection by Carbapenemase-producing Klebsiella pneumoniae (CPKP) in intensive care COVID-19 patients. Aim: to evaluate the CR-KP colonization and co- infection and evaluate the antibiotic resistance pattern. Methods: A cross -sectional study w...
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Zagazig University, Faculty of Medicine
2024-11-01
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| Series: | Microbes and Infectious Diseases |
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| Online Access: | https://mid.journals.ekb.eg/article_362371_4245fb3df4b9add8b1608a214b02b11e.pdf |
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| author | Tahia Ahmed Samir A. Afifi Ahmad M. Hassaneen Mona Radwan Rehab Ateya |
| author_facet | Tahia Ahmed Samir A. Afifi Ahmad M. Hassaneen Mona Radwan Rehab Ateya |
| author_sort | Tahia Ahmed |
| collection | DOAJ |
| description | Background: Continuous monitoring is crucial to detect infection by Carbapenemase-producing Klebsiella pneumoniae (CPKP) in intensive care COVID-19 patients. Aim: to evaluate the CR-KP colonization and co- infection and evaluate the antibiotic resistance pattern. Methods: A cross -sectional study was done on COVID-19 patients with CPKP infection in Zagazig University Hospitals where rectal swab samples were detected using XpertCarba-R Assay(Cepheid, Sunnyvale), while isolates from sputum, urine, and blood culture were identified phenotypically by VITEK® 2 (bioMérieux SA) and modified Hodge test while genotypically by XpertCarba-R Assay(Cepheid, Sunnyvale). Results: CPKP was found in 60 patients out of 140 patients (42.8%), with 34 CPKP identified from rectal swabs, 12 patients infected from diverse locations (blood, respiratory secretions, and urine), and 14 COVID-19 patients developing CPKP co-infection with colonization. A widespread resistance to all antibiotic classes was found on the antibiograms of CPKP isolates and the blaNDM was the most common genotype detected by preliminary PCR testing. Conclusion: Regarding CPKP infection, a continues focus should be taken when dealing with it, particularly among COVID-19 patients. The incidence of multi-drug resistance due to nosocomial infection can be decreased by the rigorous monitoring of colonized patients and expedite the infection control practices. |
| format | Article |
| id | doaj-art-eac6f21bf85b4507afa84db61b46e6a7 |
| institution | Kabale University |
| issn | 2682-4132 2682-4140 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj-art-eac6f21bf85b4507afa84db61b46e6a72024-12-21T21:03:54ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402024-11-01541240125210.21608/mid.2024.277993.1853362371Carbapenem-resistant Klebsiella pneumoniae in COVID-19 patients admitted to intensive care units of Zagazig University HospitalsTahia Ahmed0Samir A. Afifi1Ahmad M. Hassaneen2Mona Radwan3Rehab Ateya4Department of Clinical Pathology , Faculty of Medicine, Zagazig University, EgyptInternal Medicine, Faculty of Medicine, Zagazig University, EgyptDepartment of Clinical Pathology , Faculty of Medicine, Zagazig University, EgyptDepartment of community and occupational medicine, Faculty of Medicine, Zagazig University, EgyptDepartment of Clinical Pathology , Faculty of Medicine, Zagazig University, EgyptBackground: Continuous monitoring is crucial to detect infection by Carbapenemase-producing Klebsiella pneumoniae (CPKP) in intensive care COVID-19 patients. Aim: to evaluate the CR-KP colonization and co- infection and evaluate the antibiotic resistance pattern. Methods: A cross -sectional study was done on COVID-19 patients with CPKP infection in Zagazig University Hospitals where rectal swab samples were detected using XpertCarba-R Assay(Cepheid, Sunnyvale), while isolates from sputum, urine, and blood culture were identified phenotypically by VITEK® 2 (bioMérieux SA) and modified Hodge test while genotypically by XpertCarba-R Assay(Cepheid, Sunnyvale). Results: CPKP was found in 60 patients out of 140 patients (42.8%), with 34 CPKP identified from rectal swabs, 12 patients infected from diverse locations (blood, respiratory secretions, and urine), and 14 COVID-19 patients developing CPKP co-infection with colonization. A widespread resistance to all antibiotic classes was found on the antibiograms of CPKP isolates and the blaNDM was the most common genotype detected by preliminary PCR testing. Conclusion: Regarding CPKP infection, a continues focus should be taken when dealing with it, particularly among COVID-19 patients. The incidence of multi-drug resistance due to nosocomial infection can be decreased by the rigorous monitoring of colonized patients and expedite the infection control practices.https://mid.journals.ekb.eg/article_362371_4245fb3df4b9add8b1608a214b02b11e.pdfcovid-19carbapenemasecolonization |
| spellingShingle | Tahia Ahmed Samir A. Afifi Ahmad M. Hassaneen Mona Radwan Rehab Ateya Carbapenem-resistant Klebsiella pneumoniae in COVID-19 patients admitted to intensive care units of Zagazig University Hospitals Microbes and Infectious Diseases covid-19 carbapenemase colonization |
| title | Carbapenem-resistant Klebsiella pneumoniae in COVID-19 patients admitted to intensive care units of Zagazig University Hospitals |
| title_full | Carbapenem-resistant Klebsiella pneumoniae in COVID-19 patients admitted to intensive care units of Zagazig University Hospitals |
| title_fullStr | Carbapenem-resistant Klebsiella pneumoniae in COVID-19 patients admitted to intensive care units of Zagazig University Hospitals |
| title_full_unstemmed | Carbapenem-resistant Klebsiella pneumoniae in COVID-19 patients admitted to intensive care units of Zagazig University Hospitals |
| title_short | Carbapenem-resistant Klebsiella pneumoniae in COVID-19 patients admitted to intensive care units of Zagazig University Hospitals |
| title_sort | carbapenem resistant klebsiella pneumoniae in covid 19 patients admitted to intensive care units of zagazig university hospitals |
| topic | covid-19 carbapenemase colonization |
| url | https://mid.journals.ekb.eg/article_362371_4245fb3df4b9add8b1608a214b02b11e.pdf |
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